Recombinant Human Amphiregulin

$70.00$1,350.00

Catalog Number:P1005-10ug
                                    P1005-50ug
                                    P1005-1mg

Description:

Amphiregulin is an EGF related growth factor that signals through the EGF/TGF-α receptor, and stimulates growth of keratinocytes, epithelial cells and some fibroblasts. Amphiregulin also inhibits the growth of certain carcinoma cell lines. Synthesized as a transmembrane protein, Amphiregulin’s extracellular domain is proteolytically processed to release the mature protein. There are 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds essential for biological activity. Recombinant Human Amphiregulin is an 11.3 kDa glycoprotein consisting of 98 amino acid residues.

Source:E.coli

Synonyms:AR, AREG, Colorectum cell-derived growth factor (CRDGF)

AA Sequence:

SVRVEQVVKP PQNKTESENT SDKPKRKKKG GKNGKNRRNR KKKNPCNAEF QNFCIHGECK YIEHLEAVTC KCQQEYFGER CGEKSMKTHS MIDSSLSK

Purity:≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity:

Determined by its ability to stimulate the proliferation of mouse Balb/c 3T3 cells. The expected ED50 for this effect is 5-10 ng/ml.

Cross Reactivity:Human, Mouse

Usage:FOR RESEARCH USE ONLY

Note:The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

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SKU: P1005 Category:

Additional information

Size

10ug, 50ug, 1mg