Recombinant Human IGF-BP5

$70.00$2,700.00

Catalog Number:P1200-5ug
                                   P1200-20ug
                                   P1200-1mg

Description:

IGF-BPs control the distribution, function and activity of IGFs in various cell tissues and body fluids.  Currently, there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II.  IGF-BP5 is a 28.6 kDa, cysteine-rich, secreted protein produced by vascular smooth muscle cells.  It is the major IGF-binding protein present in bone tissue and helps potentiate the action of IGF-I on smooth muscle cells, fibroblasts, and osteoblasts.  Data shows that IGFBP-5 acts as a growth inhibitor and pro-apoptotic agent in breast cancer cells.  IGFBP-5-overexpressing mice show an increase in neonatal mortality, reduced female fertility, whole-body growth inhibition, and retarded muscle development.  Recombinant Human IGF-BP5 is a 28.6 kDa protein consisting of 253 amino acid residues.

Source:E.coli

Synonyms:Insulin-like Growth Factor-Binding Protein 5, IBP-5

AA Sequence:

MLGSFVHCEP CDEKALSMCP PSPLGCELVK EPGCGCCMTC ALAEGQSCGV YTERCAQGLR CLPRQDEEKP LHALLHGRGV CLNEKSYREQ VKIERDSREH EEPTTSEMAE ETYSPKIFRP KHTRISELKA EAVKKDRRKK LTQSKFVGGA ENTAHPRIIS APEMRQESEQ GPCRRHMEAS LQELKASPRM VPRAVYLPNC DRKGFYKRKQ CKPSRGRKRG ICWCVDKYGM KLPGMEYVDG DFQCHTFDSS NVS

Purity:≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity:The ED50 was determined by its ability to inhibit IGF-II induced proliferation of MCF-7 is ≤ 0.3 μg/ml in the presence of 15 ng/ml of human IGF-II.

Cross Reactivity:Human

Usage: FOR RESEARCH USE ONLY.

Note:The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

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SKU: P1200 Category:

Additional information

Size

5ug, 20ug, 1mg

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