Recombinant Human IL-1α

$70.00$3,510.00

Catalog Number:P1231-2ug
                                   P1231-10ug
                                   P1231-1mg

Description:

IL-1α is a non-secreted, proinflammatory cytokine produced in a variety of cells, including monocytes, tissue macrophages, keratinocytes, and other epithelial cells.  Both IL-1α and IL-1β bind to the same receptor and have similar, if not identical, biological properties.  These cytokines have a broad range of activities including the stimulation of thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the release of prostaglandin and collagenase from synovial cells.  However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine.  Recombinant Human IL-1α is an 18.0 kDa protein containing 159 amino acid residues.

Source:E.coli

Synonyms:Hematopoietin-1, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)

AA Sequence:

SAPFSFLSNV KYNFMRIIKY EFILNDALNQ SIIRANDQYL TAAALHNLDE AVKFDMGAYK SSKDDAKITV ILRISKTQLY VTAQDEDQPV LLKEMPEIPK TITGSETNLL FFWETHGTKN YFTSVAHPNL FIATKQDYWV CLAGGPPSIT DFQILENQA

Purity:≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity:

The ED50 as determined by the dose-dependent stimulation of murine D10S cells is ≤ 0.001 ng/ml, corresponding to a specific activity of ≥ 1 x 109 units/mg.

Cross Reactivity:Cow, Frog, Human, Monkey, Mouse, Pig

Usage: FOR RESEARCH USE ONLY.

Note:The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Clear
SKU: P1231 Category:

Additional information

Size

2ug, 10ug, 1mg

Reviews

There are no reviews yet.

Be the first to review “Recombinant Human IL-1α”