Recombinant Human IL-36β (IL-1F8)

$70.00$4,680.00

Catalog Number:P1270-2ug
                                   P1270-10ug
                                   P1270-1mg

Description:

The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36α (IL-1F6), β (IL-1F8) and γ (IL-1F9). IL-36β is highly expressed in psoriatic plaques, and at lower levels in various other tissues. IL-36β signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36β also functions as an agonist of NF-κB, and stimulates the production of pro-inflammatory proteins, including IL-6, IL-8, BD-2, and BD-3. Recombinant Human IL-36β is a 17.3 kDa protein containing 154 amino acid residues.

Source:E.coli

Synonyms:Interleukin-36β, IL-1F8 , IL-1H2, IL-1 eta

AA Sequence:

MREAAPKSYA IRDSRQMVWV LSGNSLIAAP LSRSIKPVTL HLIACRDTEF SDKEKGNMVY LGIKGKDLCL FCAEIQGKPT LQLKEKNIMD LYVEKKAQKP FLFFHNKEGS TSVFQSVSYP GWFIATSTTS GQPIFLTKER GITNNTNFYL DSVE

Purity:≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity:Measured by its ability to induce IL-8 production by human PBMCs.

Cross Reactivity:Human

Usage:FOR RESEARCH USE ONLY

Note:The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

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SKU: P1270 Category:

Additional information

Size

2ug, 10ug, 1mg