Recombinant Human MIP-1β (CCL4)

$70.00$2,700.00

Catalog Number:P1368-2ug
                                    P1368-10ug
                                    P1368-1mg

Description:

Both MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in host response to invading bacterial, viral, parasite and fungal pathogens, by regulating the trafficking, and activation state, of selected subgroups of inflammatory cells (e.g. macrophages, lymphocytes and NK cells). While both MIP-1α and MIP-1β exert similar effects on monocytes, their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes, and MIP-1β selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant Human MIP-1β is a 7.6 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Source:E.coli

Synonyms:Macrophage Inflammatory Protein-1β, CCL4, ACT-2

AA Sequence:

APMGSDPPTA CCFSYTARKL PHNFVVDYYE TSSLCSQPAV VFQTKRGKQV CADPSESWVQ EYVYDLELN

Purity:≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity:

Determined by its ability to chemoattract human blood monocytes using a concentration range of 5.0-20.0 ng/ml.

Cross Reactivity:Bacteria, Hamster, Human, Monkey, Mouse, Rat

Usage:FOR RESEARCH USE ONLY

Note:The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Clear
SKU: P1368 Category:

Additional information

Size

2ug, 10ug, 1mg