Recombinant Human Oncostatin M (227 a.a.)

$70.00$4,680.00

Catalog Number:P2020-2ug
                                   p2020-10ug
                                   p2020-1mg

Description:

Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis.  Produced by activated T cells, monocytes and Kaposi’s sarcoma cells, OSM can exert both stimulatory and inhibitory effects on cell proliferation.  It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi’s sarcoma cells, but inhibits the growth of some normal and tumor cell lines.  It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptors in hepatoma cells.  OSM shares several structural and functional characteristics with LIF, IL-6, and CNTF.  Human OSM is active on murine cells.  Recombinant Human Oncostatin M is a 25.7 kDa protein, containing 227 amino acid residues (full length precursor).

Source:E.coli

Synonyms:OSM

AA Sequence:

AAIGSCSKEY RVLLGQLQKQ TDLMQDTSRL LDPYIRIQGL DVPKLREHCR ERPGAFPSEE TLRGLGRRGF LQTLNATLGC VLHRLADLEQ RLPKAQDLER SGLNIEDLEK LQMARPNILG LRNNIYCMAQ LLDNSDTAEP TKAGRGASQP PTPTPASDAF QRKLEGCRFL HGYHRFMHSV GRVFSKWGES PNRSRRHSPH QALRKGVRRT RPSRKGKRLM TRGQLPR

Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity:

The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 2 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.

Cross Reactivity:Dog, Human, Monkey, Mouse, Pig, Rat

Usage:FOR RESEARCH USE ONLY

Note:The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Clear
SKU: P2020 Category:

Additional information

Size

2ug, 10ug, 1mg

Reviews

There are no reviews yet.

Be the first to review “Recombinant Human Oncostatin M (227 a.a.)”