Recombinant Human OPG

$70.00$1,350.00

Catalog Number:P1025-10ug
                                   P1025-50ug
                                   P1025-1mg

Description:

Osteoprotegerin (OPG) is a member of the TNFR superfamily that can act as a decoy receptor for RANKL.  Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage.  OPG is expressed in a wide variety of tissues, including the adult heart, lung, kidney, liver, spleen, prostate, lymph node, and bone marrow.  OPG is secreted both as a monomeric and a dimeric protein.  Its primary structure consists of seven distinct domains, four of which correspond to the extracellular cysteine-rich domains of TNFR proteins and constitute the soluble OPG.  Recombinant Human OPG is a soluble 20.0 kDa protein containing 174 amino acid residues.

Source:E.coli

Synonyms:TNFRSF11B, Osteoprotegerin, OCIF (osteoclastogenesis inhibitory factor), TR1

AA Sequence:

METFPPKYLH YDEETSHQLL CDKCPPGTYL KQHCTAKWKT VCAPCPDHYY TDSWHTSDEC LYCSPVCKEL QYVKQECNRT HNRVCECKEG RYLEIEFCLK HRSCPPGFGV VQAGTPERNT VCKRCPDGFF SNETSSKAPC RKHTNCSVFG LLLTQKGNAT HDNICSGNSE STQK

Purity:≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity:Determined by its ability to inhibit TRAIL-induced apoptosis of LN-18 glioblastoma cells.

Cross Reactivity:Human, Mouse, Rat

Usage:FOR RESEARCH USE ONLY

Note:The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

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SKU: P2018 Category:

Additional information

Size

10ug, 50ug, 1mg