Recombinant Human TGF-β1 (CHO derived)

$75.00$180.00

Catalog Number:P2142-2ug
                                   P2142-10ug

Description:

The three mammalian isoforms of TGF-β, TGF-β1, β2, and β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility, as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes, including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes, which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and/or induction of conformational changes by proteins such as thrombospondin-1. TGF-β1 is the most abundant isoform secreted by almost every cell type. It was originally identified for its ability to induce phenotypic transformation of fibroblasts, and recently it has been implicated in the formation of skin tumors. Recombinant Human TGF-β1 derived from HEK293 cells is a 25.0 kDa protein with each subunit containing 112 amino acid residues, linked by a single disulfide bond.

Source:CHO cells

Synonyms:Transforming Growth Factor-β1, Differentiation inhibiting factor, Cartilage-inducing factor

AA Sequence (monomer):

ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASAAPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CS

Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity:

The ED50 was determined by TGF-β1’s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg

Cross Reactivity:Chicken, Cow, Dog, Donkey, Frog, Human, Mink, Monkey, Mouse, N/A, Pig, Rabbit, Rat

Usage: FOR RESEARCH USE ONLY.

Note:The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

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SKU: P2142 Category:

Additional information

Size

2ug, 10ug