$75.00 – $180.00
BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residues and a propeptide of 110 amino acid residues. Recombinant Human/Murine/Rat BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions.
Synonyms:Brain Derived Neurotrophic Factor, Abrineurin
AA Sequence (monomer):
MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR
Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.
Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 0.5-1.0 μg/ml.
Cross Reactivity:Chicken, Frog, Guinea Pig, Hamster, Human, Human + Virus, Monkey, Mouse, N/A, Rat, Tadpole
Usage:FOR RESEARCH USE ONLY
Note:The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.